Maximizing Tumor Immunity With Fractionated Radiation
نویسندگان
چکیده
منابع مشابه
Radiation holidays stimulate tumor immunity
Radiotherapy is a standard treatment for cancer and is used since a long time as a stand-alone therapy or in combination with surgery and systemic therapies including immunotherapy. Its acts through induction of irreversible DNA damage to which tumor cells are more susceptible because of frequent mutations in DNA repair pathways. Fractioned radiotherapy, given as daily low doses during multiple...
متن کاملRadiation-induced changes in established tumor immunity.
The effect of radiation therapy on tumor growth and on specific immune resistance to tumor growth was investi gated in mice actively sensitized to a syngeneic sarcoma. While radiation was therapeutic for tumor growth in the radiated field, it was also found that extensive-field radia tion, but not limited-field radiation, could facilitate the growth of tumors in unradiated parts of the animal. ...
متن کاملSynergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor.
We have shown previously that arsenic trioxide (ATO) preferentially shutsdown tumor blood flow, leading to pronounced cell death in the central part of the solid tumor with a minimal effect on the surrounding normal tissues. On the basis of the histopathological and tumor perfusion studies, we hypothesized that the tumor control rate of locally advanced solid tumors would increase after the com...
متن کاملIntratumoral IL-15 potentiates radiation-induced anti-tumor immunity
Radiotherapy (RT) can induce T cell-mediated anti-tumor immune responses by multiple mechanisms but is often unable to overcome immunosuppression in the tumor microenvironment. The common gamma-chain cytokines interleukin (IL)-2 and IL-15 promote the proliferation of activated T cells and, therefore, are prime agents for immunotherapy strategies aimed at sustaining anti-tumor T cell responses. ...
متن کاملAdenosine regulates radiation therapy-induced anti-tumor immunity
Radiation therapy (RT) induces immunogenic cell death and dose-dependent release of ATP in the tumor microenvironment (TME), triggering maturation and activation of tumor-resident dendritic cells (DCs). However, extracellular ATP is rapidly catabolized to adenosine by ectonucleotidases CD39 and CD73, which are expressed by tumor cells and immune cells in the TME. Adenosine has pleiotropic immun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2012
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2011.09.049